Performance of Molecular Approaches for Aspergillus Detection and Azole Resistance Surveillance in Cystic Fibrosis
نویسندگان
چکیده
1 Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Rennes, Rennes, France, 2 Centre de Ressources et de Compétences de la Mucoviscidose Adulte, Centre Hospitalier Universitaire de Rennes, Rennes, France, 3 Centre de Ressources et de Compétences de la Mucoviscidose Pédiatrique, Centre Hospitalier Universitaire de Rennes, Rennes, France, 4 Université de Rennes 1, INSERM, Institut de Recherche en Santé, Environnement et Travail – UMR_S 1085, Rennes, France
منابع مشابه
First description of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in France.
Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description o...
متن کاملAzole resistance surveillance in Aspergillus fumigatus: beneficial or biased?
Azole resistance is a growing concern with Aspergillus fumigatus, and may cause increased mortality in patients with azole-resistant invasive aspergillosis (IA). Microbial surveillance has been recognized as a fundamental component of resistance management. Surveillance information may be used to inform decisions regarding health services and research funding allocation, to guide local infectio...
متن کاملAntibiotic resistance properties and molecular characterization of Pseudomonas aeruginosa strains from patients with cystic fibrosis (CF) referred to Gholhak Pathobiology Laboratory in Tehran city during 2016-2018
Background and Objectives: Pseudomonas aeruginosa isolates from the lungs of cystic fibrosis (CF) patients are often heterogeneous and antibiotic resistant strains. Our work therefore focused on the antibiotic resistance properties of these P. aeruginosa strains isolated from Iranian patients, as well as the genetic diversity analysis by a repetitive-element-based molecular assay. Methods: This ...
متن کاملAspergillus fumigatus in the cystic fibrosis lung: pros and cons of azole therapy
Aspergillus fumigatus is the main fungus cultured in the airways of patients with cystic fibrosis (CF). Allergic bronchopulmonary aspergillosis occurs in ~10% of CF patients and is clearly associated with airway damage and lung function decline. The effects of A. fumigatus colonization in the absence of allergic bronchopulmonary aspergillosis are less well established. Retrospective clinical st...
متن کاملHigh prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole.
Aspergillus fumigatus is the most frequent fungus found in the sputum of cystic fibrosis (CF) subjects. Itraconazole is prescribed for allergic bronchopulmonary aspergillosis (ABPA) or Aspergillus bronchitis in CF subjects. We hypothesized that A. fumigatus isolates in the sputum of CF subjects with previous exposure to itraconazole was associated with higher prevalence of azole resistance. Fro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2018